Conference Introduction

With the rapid development of in vivo measurement techniques, aptamer screening technique, molecular imaging techniques, molecular typing technology, gene and protein techniques, etc., precision medicine has become an important field to solve clinical diagnosis and treatment problems, lead medical frontier development and clinical translation research, and improve disease prevention and treatment. And it has been elevated to "National Development Strategy" of China. Suzhou Institute of Nanotechnology and Nano-Bionics, CAS-The Key Laboratory of Nano-Biological Interfaces of CAS will hold the fourth " Nano Health - In vivo Biometrics and Precision Medicine Forum" on 23th-24th Oct, 2024, Suzhou. Focusing on the world's leading edge of science and technology, closely following the country's major needs, and facing the people's life and health, this forum will invite well-known experts to introduce the advanced technology progress and achievements in this field, and provide a platform for exchanges and demonstrations for people engaged in in vivo biometrics, molecular medicine, molecular imaging and clinical translational research.

Organization

Hosts

    • Suzhou Institute of Nano-Tech and Nano-Bionics , CAS



Organizers

    • Suzhou Institute of Nano-Tech and Nano-Bionics , CAS
    • CAS Key Laboratory for Nano-Bio Interface
    • Nanopolis Suzhou Co., Ltd.

Main topics

Topics discussed at this meeting included but are not limited to:

2023 Agenda arrangement

Date: Mar. 1
Location: A209-A210
Date: Mar. 2
Location:A209-A210
  • 08:30-8:55
    Analysis of Chemical Expression of Electroencephalogram Signal
    Yang Tian,Professor of East China Normal University

  • 08:55-09:20
    On the Essence of Life Phenomenon from the 'View of Gasification' of Internal Classic
    Yi Zhou,Professor of Chengdu University of Traditional Chinese Medicine

  • 09:20-09:45
    Research of Tumor Diagnosis and Treatment Integration based on Melanin Nanoparticles
    Ruiping Zhang,President of First Hospital of Shanxi Medical University

  • 09:45-10:10
    In Vivo Imaging and Measurement
    Haibin Shi,Professor of Soochow University

  • 10:10-10:30
    Tea Break

  • 10:30-10:55
    Structural Regulation and Precision Imaging of Fluorescent Probe
    Xiaobing Zhang,Professor of Hunan University

  • 10:55-11:20
    Enzyme Assisted Peptide Folding, Self-assembly and Bioactivity
    Zhimou Yang,Professor of Nankai University

  • 11:20-11:45
    Near-infrared Imaging-guided Stem Cell Fate Monitoring and Modulation
    Guangcun Chen,Professor of Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences

  • 12:00-13:30
    Lunch

  • 13:30-13:55
    Nanoconfinement Controlled Electrochemistry for Single Molecule Measurement
    Yitao Long,Professor of Nanjing University

  • 13:55-14:20
    Imaging Studies of Cerebrovascular Diseases
    Shenghong Ju,Professor of Southeast University

  • 14:20-14:45
    Treatment of Brain Diseases with Ultra-Small Nanoprobe
    Zhen Li,Professor of Soochow University

  • 14:45-15:10
    The PEE Strategy to Improve Quantum Yields and Hepatic Clearance of Near-Infrared II Dyes
    Jianfeng Li,Professor of ShanghaiTech University

  • 15:10-15:35
    Nanomedicines Applied for Immunotherapy
    Mingzhou Ye,Professor of Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences

  • 15:10-15:30
    Tea Break

  • 15:50-16:15
    Self-assembled Peptide Functional Systems and their Application for Tumor Phototherapy
    Xuehai Yan,Professor of Institute of process engineering, Chinese Academy of Sciences

  • 16:15-16:40
    Biomedical Used Optical Functional Materials
    Dan Ding,Professor of Nankai University

  • 16:40-17:05
    Innovative Microwave and Optoelectronic Systems for Antibody - free Cell Separation
    Hongwei Wu,Chair Professor of Fudan University

  • 17:05-17:30
    Application of Nucleic Acid Based Drugs in Organism and Organoids
    Kai Wang,Professor of Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences

  • 17:30-20:00
    Conference Banquet (Invitation Only)

Speakers
Mingzhou Ye
(Professor of Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences)
Nanomedicines Applied for Immunotherapy

 Biography:Ye Mingzhou, Researcher has been introduced through the National High-level Talent Program and is supported by the "100 Talents Program" of the Chinese Academy of Sciences. After receiving his Ph.D. from Zhejiang University in 2015, he was engaged in postdoctoral research at Zhejiang University and the University of Wisconsin-Madison. In 2021, he joined the SINANO, CAS as a full-time researcher.Ye Mingzhou has long been committed to the application of nanomedicines in immunotherapy. Through the creation of novel stimulus-responsive biomaterials, the precise delivery and controlled release of drug molecules/proteins/genes has been realized to effectively treat major diseases such as tumors, drug-resistant bacterial infections and sepsis, etc. One aspect of his work is to explore the immune regulation mechanism of biological materials and the other is to construct composite nanostructures to realize immunotherapy for various diseases. In recent years, as the first author / correspondent author, he has published more than ten papers in internationally renowned journals such as Nature Nanotechnology, Matter, Advanced Materials, Advanced Functional Materials and so on, and applied for 4 US patents.

Abstract: Immune imbalance is a key causative mechanism to a range of major diseases. Therefore, immunotherapy has become an increasingly important treatment. However, immunotherapy still has huge limitations at this stage, and the immune escape of tumors and infection-induced inflammatory storms are still major problems that have not been solved clinically. Features targeting, smart response and versatility, nanomedicines can be loaded with a variety of immunomodulatory factors for controlled release in lesions, thus having intrinsic advantages for disease treatment. Here, I will introduce a number of new applications of nanomedicines in the field of immunotherapy, as well as some potential development prospects.

Speakers
Wei Wu
(Chair Professor of Fudan University)
Innovative Microwave and Optoelectronic Systems for Antibody-free Cell Separation

 Biography: TBD
Abstract: TBD

Speakers
Yi Zhou
(Professor of Chengdu University of Traditional Chinese Medicine)
On the Essence of Life Phenomenon from the

 Biography:Yi Zhou, Ph.D., Professor at the School of Basic Medical Sciences, Chengdu University of Chinese Medicine, Standing Member of the Inner Canon Research Professional Committee of the World Federation of Chinese Medicine Societies, and Standing Member of the Inner Canon Branch of China Association of Chinese Medicine. Mainly engaged in the teaching and scientific research of "Yellow Emperor’s Inner Canon", hes dedicated to the research of academic thoughts and clinical application of "Yellow Emperor’s Inner Canon".

Abstract: TBD

Speakers
Guangcun Chen
(Professor of Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences)
Near-infrared Imaging-guided Stem Cell Fate Monitoring and Modulation

Biography:Dr. Guangcun Chen is a full Professor in Suzhou Institute of Nano-Tech and Nano-Bionics (SINANO), Chinese Academy of Sciences. He got his Ph.D from Zhejiang University in 2011. After that, He joined SINANO as an Assistant Professor in October 2011. He was promoted to Associate Professor in 2015, then Full Professor in 2021. So far, he has published 52 journal papers on the academic journals, such as Adv. Mater., JACS, Adv. Funct. Mater., Adv. Sci. and so on. He was selected by the Youth Innovation Promotion Association of the Chinese Academy of Sciences. Based on his research achievements, he was recognized by several awards and honors including High-level Talents of "Six Talent Peaks in Jiangsu Province", the “333” talent project of Jiangsu Province, the first prize of 2017 Jiangsu Provincial Science and Technology Award.

Abstract:Stem cell-based regenerative medicine holds great promise in clinical practices. However, the fate of stem cell after transplantation, including the distribution, viability, and differentiation capability, is not fully understood, which is critical to understand the process and the underlying mechanism of regeneration for better therapeutic effects. My research focuses on cell fate monitoring and regulation in regenerative medicine. By using multidisciplinary technologies, I established a novel method for efficient and safe labeling of stem cells with NIR-II fluorescent Ag2S quantum dots and established a novel imaging platform for in vivo stem cell tracking with deep tissue penetration and high spatiotemporal resolution. With the novel imaging platform, I systematically revealed the function and fate of transplanted stem cells and the molecular mechanisms involved in tissue regeneration. Moreover, under the guidance of accurate NIR-II imaging, I developed new technologies for cell paracrine, differentiation regulation and neural regeneration for Alzheimer’s disease treatment. These studies provide new approaches for the application of multidisciplinary technology in regenerative medicine.

Speakers
Yitao Long
(Professor of Nanjing University )

 Biography: Yi-Tao Long received his PhD from Nanjing University with Prof. Hong-Yuan Chen in 1998. After completing postdoctoral studies at Heidelberg University, he worked at the University of Saskatchewan, the University of Alberta, Canada, and the Department of Bioengineering at UC Berkeley. He then was appointed as a professor at East China University of Science and Technology in 2007. Since 2019, he worked as a full professor at Nanjing University. His main research focuses on the electrochemistry at nanoconfinement which involves nanopore electrochemistry, biointerfaces nano-spectroelectrochemistry and integrated biosensors for life science. He has published over 300 peer-reviewed scientific papers in high-impact journals, including Nat. Nanotech., Nat. Chem., J. Am. Chem. Soc., Angew. Chem. Int. Ed., as well as 5 books/chapters and 37 patents. He currently serves as Associate Editor for Chemical Science, and Editorial Board/Advisory Board Member of ChemElectroChem, Research, Theranostics, Microchimica Acta, and was a founding Associate Editor for ACS Sensors (2015-2018).

Abstract: Measurement at the single molecule level has greatly enhanced the precision and depth of our knowledge about living system. In recent years, biological nanopore acting as a single biomolecule interface has evolved into a priming strategy for single molecule analysis with high spatiotemporal resolution and ultra-sensitivity. The electrochemical sensing mechanism depends greatly on the ionic current changes during the translocation of target molecule, which is also defined as current blockage. It plays key role in the nanopore based sensing capability and further applications, that includes single-molecule DNA sequencing, peptide/protein sensing, detecting rare species, resolving the hidden intermediates and enzymatic process measurement. Nonetheless, challenges arise when the current blockage mechanism is applied to the biomolecule detection in real-life samples and amino acids discrimination in protein sequencing due to the limited specificity and resolutions. Herein, we revisit the underlying nanoconfined controlled electrochemical sensing mechanism and propose a modified conductance model induced by the noncovalent interactions between the single biomolecule interface and the target molecule. This understanding of nanopore current blockage provides a new strategy to achieve volume difference sensing at the atomic level with highly specific current events, promote the nanopore protein sequencing and its applications in real-life systems.

Speakers
Hao Wang
(Professor of National Center for Nanoscience and Technology)
In Vivo Self-assembled Peptide-nanoprobes for Tumor Imaging

Biography: Wang Hao, Humboldt Scholar, National Distinguished Young Scholars. He is currently director of the Nanobiology Effects and Safety Laboratory at the National Center for Nanoscience and TechnologyHe received his Doctor of Science degree from Nankai University in 2005. He then worked at the University of Wurzburg in Germany and in 2007 at the UCLA on nanotechnology in cancer diagnosis and treatment. In 2011, he joined the National Center for Nanoscience and Technology.His current research interest is medical polymer materials. A new concept of in vivo assembly was proposed to achieve the targeting, enrichment and retention of materials at focal sites, and a new medical polymer material system was developed, which opened up a new way for the diagnosis and treatment of serious diseases. In Nat. Commun., Angew.Chem. Int.Ed., JACS, Adv. Mater. More than 200 papers have been published in such journals. 

Abstract: In order to reduce the recurrence rate and improve the postoperative quality of life of patients, imaging-guided accurate resection of tumors becomes very important. The development of imaging probes with high specificity and sensitivity is an important scientific issue in the field of biomedical materials. We developed the "in vivo self-assembly" strategy to construct nanoprobes in situ in tumors, which can not only overcome multiple biological barriers during in vivo transmission, making precise customization according to the heterogeneous pathological characteristics of tumors, but also improve the specificity and sensitivity of nanoprobes by taking advantage of the unique biological effects of efficient enrichment and long-term retention. Performance imaging has been obtained on a variety of tumor models.

Speakers
Zhimou Yang
(Professor of Nankai University)
Enzyme Assisted Peptide Folding, Self-assembly and Bioactivity

Biography: Zhimou Yang, born 1978 in Guangdong Province, China. Dr. Yang received his BS from Nanjing University in 2001. He obtained his PhD in 2006 from the Hong Kong University of Science and Technology under the supervision of Professor Bing Xu. Before starting his independent research at Nankai University in March 2009, he was a postdoctoral fellow with Prof. Matthew Bogyo at Stanford Medical School. His research interests focus on biomedical applications of peptide-based hydrogels including hydrogels of drug-peptide amphiphiles for drug delivery, hydrogels of bioactive peptides for tissue engineering, and hydrogels as vaccine adjuvants, etc. He has published around 100 corresponding authored papers in the field of peptide self-assembly. He obtained the National Science Fund for Distinguished Young Scholars from National Natural Science Foundation of China in 2018.

Abstract:Most of peptide segments in proteins are constrained into certain conformations, especially for bioactive peptides. However, when these peptides are separated from proteins, they failed to fold into their inherent conformations and therefore lost their functionalities.The generation of α-helical peptide and α-helix mimetic is very important to achieve biological functions of peptides or inhibit protein-protein interactions. Several strategies have been developed to induce α-helix conformation of short peptides including constrained peptides and foldamers. We recently found that enzyme instructed self-assembly (EISA) provided a unique pathway to trigger the formation of α-helix of short peptides, which was unable to be achieved by other conventional methods. The nanomaterials formed by EISA held several advantages including more stable nanostructures, better stability against enzyme digestion, enhanced cellular uptake, bigger fluorescence signal to noise ratio, and higher efficiency to inhibit cancer cells and tumors. Using different pathways to trigger peptide self-assembly, we could fold bioactive peptides into α-helix and b-sheet and we developed a self-assembling peptides with superior bioactivity to the growth factor of IGF-1. We envisioned that EISA, in combine with kinetic control of enzymatic reaction, would lead to nanomaterials with well controlled nanostructures and biofunctions.

Speakers
Ruiping Zhang
(President of First Hospital of Shanxi Medical University)
Research of Tumor Diagnosis and Treatment Integration based on Melanin Nanoparticles

Biography: President of First Hospital of Shanxi Medical University, Level-2 professor, doctoral supervisor, postdoctoral co-supervisor

• Selected as leading talent of the national Ten-thousand Talents Program, candidate of the national 100 Million Talents Project, national outstanding professional and technical talent, State Council Special Allowance Expert, young and middle-aged expert with outstanding contributions to national hygiene and health

 Expert of the 1st and 2nd review for National Natural Science Foundation of China, Director of the Key Laboratory of Shanxi Province

• Director of Engineering Technology Research Center of Shanxi Province, Director of Engineering Research Center of Shanxi Province

• Leader of a team recognized as Key Team for S&T Innovation of Shanxi Province

• 5 key projects and general projects of the National Natural Science Foundation, published more than 80 papers on SCI journals as the first and corresponding author, published more than 60 papers in SCI journals in Zone 1, some of which were published on internal top-notch journals such as Nature Communications, Advanced Materials, PNAS, JACS, etc.

• Won as the 1st Accomplisher the 1st prize (2 items) of Shanxi Natural Science and Technology and 2nd prize of China Anti Cancer Association, etc.

• Chief Editor of Nano Biomedicine and Engineering and Associate Editor of Radiology Science 

Abstract:In recent years, the rapid advancement of nanomedicine has provided new opportunities for tumor diagnosis and treatment, and real-time monitoring of tumor locations with the help of a variety of molecular imaging methods is of great significance for improving the accuracy of tumor diagnosis and improving prognosis. However, the toxicity, degradability and biocompatibility of nanomaterials hamper their further clinical applications. As an endogenous natural substance in organisms, melanin features good biosafety and clinical transformation prospects. Besides, due to easier chelation between the natural melanin nanoparticles and metal ions, as well as desired near-infrared light absorption and strong photothermal conversion efficiency, they can play a role in a variety of biological imaging and tumor treatment fields. The construction of multifunctional diagnostic and therapeutic nanoprobes by modifying natural melanin nanoparticles has high clinical transformation application value for achieving safer and more efficient tumor diagnosis and treatment integration.

Speakers
Fan Wang
(Professor of Peking University)
Molecular Imaging of Nuclear Medicine and Accurate Diagnosis and Treatment of Tumors

 Biography: Wang Fan, Distinguished Professor of Boya, Peking University, Director of Medical Isotope Research Center, Peking University, Visiting Researcher (PI) of Institute of Biophysics, CAS, Distinguished Researcher (PI) of Guangzhou Laboratory, and Chairman of Molecular Imaging Branch, Chinese Biophysics Society. In 1997, she received Ph.D. (Isotope Technology) from China Institute of Atomic Energy. She received her postdoctoral training at Oak Ridge National Laboratory and at Dr. Welchs Lab in the Washington University in St Louis from 1998 to 2000, focusing on research on radiopharmaceuticals for tumor targeted imaging diagnosis and treatment. After returning to China in October 2000, she established the Medical Isotopes Research Center, Peking University to continue the research of molecular probe, molecular imaging, tumor radio-targeted therapy, diagnosis and treatment of radiopharmaceuticals. She successively presided over the national "Scientific and Technological Breakthrough" Project, the "863" Project, major scientific and technological special project of the national "Major New Drug Creation", the national major scientific research instrument development project and the national natural science foundation key project, key international cooperation projects, etc. In 2011, she won the National Science Fund for Distinguished Young Scholars.

Abstract: Nuclear medicine molecular imaging is an important part of precision medicine, and plays an irreplaceable role in the early diagnosis, staging, prognosis evaluation, individualized treatment and efficacy monitoring of diseases, especially tumors. Whats the most worth mentioning is 18F-FDG PET/CT imaging, which is the gold standard for imaging diagnosis and staging of multiple malignant tumors. Compared with PET technology, SPECT, another nuclear medicine molecular imaging technology, has lower equipment and drug costs, higher clinical penetration rate and better application basis. However, the lack of effective imaging agent like 18F-FDG limits the play of SPECT imaging technology in tumor diagnosis and efficacy evaluation. This report will focus on the research progress and clinical application of SPECT imaging drugs.

Speakers
Xuehai Yan
(Professor of Institute of process engineering, Chinese Academy of Sciences)
Self-assembled Peptide Functional Systems and Their Application for Tumor Phototherapy

Biography: Dr. Yan is a full professor at the Institute of Process Engineering, Chinese Academy of Sciences. He won the National Science Fund for Distinguished Young Scholars in 2020, was selected as a young and middle-aged scientific and technological innovation leader of the Ministry of Science and Technology in 2018, and is the deputy director of the State Key Laboratory of Biochemical Engineering and the director of the Department of Biological Formulations and Biomaterials. His research interest is mainly focused on biomolecular self-assembly and engineering, including peptide and protein materials, assembly drugs, assembly mechanism, and new technologies for anti-inflammatory, antibacterial and anti-tumor therapy. He has published 180 peer reviewed papers with citation of more than 14000 times, and has been successively selected into the list of highly cited researchers of Clarivate and highly cited scholars of Elsevier China. He serves as deputy editor of ACS Applied Materials and Interfaces and GEE as well as advisory editorial members of ChemBioChem, ACS Appl Bio Mater. and ChemSystemsChem etc.

Abstract:Oligopeptides (small molecular peptides) have the primary structure same to proteins, both of which are composed of amino acids. They have the advantages of programmable design of molecular sequence, flexible and controllable assembled structures, etc. Oligopeptides have been developed into a class of important building blocks, providing a new opportunity for creating and developing new biomedical materials. It was found that "liquid-liquid phase separation" is the "promoter" of self-assembly of small biological molecules including peptides, which plays a decisive role in the nucleation and growth of the assembly. The formation of solute-rich droplets driven by hydrophobic interaction is an entropy driven process, while the transition from droplets to more thermodynamic stable assemblies (such as nanofibers, nanoparticles and nanocrystals) is an enthalpy driven process and is dominated by hydrogen bonding. Based on this finding, a new mechanism of LLPS-mediated nucleation and growth was proposed, which makes sense for understanding the supramolecular self-assembly process and precisely controlling the structure and function of the assembly. Based on the insight into the mechanism of peptide self-assembly, a series of photodynamic/photothermal functional assemblies were further accurately constructed to achieve tumor imaging and effective treatment at the level of living mice. Furthermore, the functions of tumor targeting and immune response can be achieved by designing the peptide sequence. This study may provides a toolbox for construction of assembled nanodrugs with potential of clinical translation.

Speakers
Daiwen Pang
(Professor of Nankai University)
Multi-hierarchical Equilibration of Quantum Dots

Biography: Dr. Dai-Wen Pang, a distinguished professor of chemistry at Nankai University and the Head of SAC/TC279/WG10, focuses on biomedical quantum dots (BioQDs, fluorescent semiconductor nanocrystals) for biolabeling and dynamic bioimaging. He has proposed the principle of “multi-hierarchical equilibration of QDs”, and first broken through the stability dilemma that limits their application on a large scale for 42 years (1980-2022), making the large-scale applications possible in biolabeling and optoelectronic display. Their QD light diffusion plate technology has been applied to >2 million QD TV. For his outstanding contributions to the development of QD-based methodologies for single-virus tracking, he was elected as a fellow of the American Institute for Medical and Biological Engineering (AIMBE) and fellow of the Royal Society of Chemistry in 2021.

Abstract: Quantum dots (QDs) are promising candidates of fluorophores for a wide variety of applications in biomedical imaging, and optoelectronic devices, etc. They can be regarded as a multi-hierarchical assembly, consisting of an inorganic semiconductor nanocrystal core, a ligand layer, and sometimes a confinement shell. Each single hierarchy of QDs has been systematically studied and now it is not difficult to achieve a single one of properties of QDs to the extreme. However, it is very difficult that their comprehensive properties are perfectly good. In practical application scenarios or environments, the intrinsic linkage and balance among single hierarchical structures must be comprehensively considered. Therefore, multi-hierarchical equilibration tuning of QDs is highly required. To this end, we propose that only by comprehensive equilibration of multi-hierarchical structures of QDs including the inorganic semiconductor nanocrystal core, confinement shell and surface ligands, especially together with potential application scenarios (microenvironment), we can fabricate QDs with excellent properties. In this presentation, we will discuss in detail our insights into developing and exploiting the excellent optical properties of QDs.

Speakers
Chunhai Fan
(Professor of Shanghai Jiao Tong University )
Speakers
Zijian Guo
(Professor of Nanjing University, Academician of the Chinese Academy of Science)
Addressing the Clinical Challenges of Platinum-based Anticancer Drugs

 Biography: Zijian Guo received his PhD degree from the University of Padua in 1994, and worked as a postdoc fellow and a research associate at the University of London, the University of British Columbia and the University of Edinburgh successively. He joined Nanjing University as a professor in 1999 and served as the director of the State Key Laboratory of Coordination Chemistry from 2000 to 2009 and the dean of the School of Chemistry and Chemical Engineering from 2006 to 2014. He was elected to the member of the Chinese Academy of Sciences in 2017 and the fellow of the Third World Academy of Sciences (TWAS). He is currently the director of the Chemistry and Biomedicine Innovation Center (ChemBIC) of Nanjing Univerisity. He was the winner of the Luigi Sacconi Medal of Italian Chemical Society in 2016 and the Outstanding Achievement Award of Asian Society of Biological Inorganic Chemistry in 2020.

Abstract: Platinum-based anticancer drugs play an important role in the treatment of various malignancies such as colorectal and testicular cancers. However, drug resistance and side effects are challenging problems that hinder their wider clinical applications. Chemical biology approaches could be applied for elucidating the mechanism of action of different platinum anticancer drugs, and provides important tools for understanding the biological effects of platinum anticancer complexes in cellular energy conversion, metabolism and apoptosis.In this talk, I will focus on the molecular design of platinum-based antitumor complexes with multi-specific targeting potentials. These results demonstrated that in addition to DNA binding, bio-energetic pathways may also play crucial roles in the antitumor activity of mitochondrion-targeted platinum complexes. The combination of chemotherapy and immunotherapy in one molecule offers potential superiority for the treatment of triple negative breast cancer. 

Speakers
Jinghong Li
(Professor of Tsinghua University, Academician of the Chinese Academy of Science)
Chemical Metrology in Major Public Health Emergencies

      Biography: Professor Jinghong Li is currently Academician of Chinese Academy of Sciences, Professor in the Department of Chemistry at Tsinghua University, Director of Academic Committee of Department of Chemistry, the Head of Analysis Center, Tsinghua University. 

He received his B.Sc. from University of Science and Technology of China in 1991, and Ph.D. from Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS) in 1996. His current interests of research and teaching include electroanalytical chemistry, bioelectrochemistry, single-cell chemical analysis and nanoscopic electrochemistry. He has published over 400 papers in international, peer-reviewed journals such as Nature Nanotech., Nature Biomedical Engineering, Nature Protocol, Nature Commun., J. Am. Chem. Soc., Angew. Chem., Anal. Chem. etc. He is RSC fellow and Highly Cited Researchers 2015-2022 in Chemistry, Materials (Thomson Reuters). He was winner of the 2nd Prize of National Natural Science Award as the First Accomplisher and the 1st Prize of National Science Award of the Ministry of Education, etc. He’s now Associate Editor and on the editorial committee of more than 20 international journals, incl. Chem. Soc. Rev., ACS Sensors, Biosensors Bioelectronics, Small Methods,ChemRxiv.

      Abstract: The science of chemical metrology of biomolecules aims to reveal the molecular information about complex living systems. It plays a key role in responding to major public health emergencies, and also faces the challenges of greater accuracy, faster, easier, and higher detection throughput. In recent years, in the activities carried out for epidemic prevention and control of SARS, COVID-19 pandemic, monkeypox and other virulent infectious diseases, our research group has the double-marker immunochromatography of "SARS" virus antigens, explored a fast detection method and instrument for coronavirus nucleic acid with single-base resolution and discovered the characteristics of the nucleic acid secondary structure of monkeypox virus genome, making positive contributions to the epidemic prevention and control of major public health emergencies. The advancement of chemical metrology of complex living systems will promote pathogen detection, study of pathogenicity, drug screening and vaccine development and protect people's lives and health.

Speakers
Weihong Tan
(Professor of Shanghai Jiao Tong University, Academician of the Chinese Academy of Science )
TBD

 Biography: TBD
Abstract: TBD

Speakers
Dan Ding
(Professor of Nankai University)
Biomedical Used Optical Functional Materials

Biography: Prof. Dan Ding received his PhD degree in Polymer Chemistry and Physics from Nanjing University in 2010. After a postdoctoral training in the National University of Singapore, he joined Nankai University in March 2013, where he is currently a professor in the College of Life Sciences and State Key Laboratory of Medicinal Chemical Biology. His current research interest focuses on the design and preparation of nanomedicines and new molecular imaging probes as well as exploration of their biomedical applications. So far, he has published more than 100 papers in the journals such as Nat. Commun., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Adv. Mater. and so on. His h-Index is 65.

Abstract: Development of efficient fluorescent probes with intense far-red/near-infrared (FR/NIR) emission (> 650 nm) is of great importance in biosensing and bioimaging research. To date, a large variety of materials, including organic dyes, fluorescent proteins and inorganic quantum dots (QDs), has been extensively studied for the purpose of FR/NIR fluorescence imaging. Organic dyes and fluorescent proteins, however, suffer from limited molar absorptivity and low photobleaching thresholds, while inorganic QDs are highly cytotoxic in an oxidative environment: this has greatly limited the scope of their in vitro and in vivo applications. Exploration of novel FR/NIR fluorescent probes with a high biological compatibility, strong photobleaching resistance, and efficient light emission is highly desirable for biosensing and bioimaging. Herein, we designed and synthesized new FR/NIR fluorescent probes based on semiconducting polymers or fluorophores with aggregation-induced emission (AIE) characteristics. We then explored the biomedical applications of these new fluorescent probes, which were demonstrated as very promising probes for in vitro and in vivo biosensing and bioimaging applications.

Speakers
Ning Gu
(Professor of Nanjing University, Academician of the Chinese Academy of Science)
Study on Single/multi-cell Thermometry System

 Biography: Gu Ning is Professor and Doctoral Supervisor of Nanjing University, Academician of CAS, member of the academic department of the Chinese Academy of Medical Sciences, Distinguished Professor of "Changjiang Scholars" of the Ministry of Education, winner of the National Science Fund for Distinguished Young Scholars, and one of the 7th "National Outstanding Scientific and Technological Workers". Besides, hes also a member of the China Micron and Nanotechnology Society and the American Institute for Medical and Biological Engineering (AIMBE Fellow). Hes mainly engaged in the research of biomedical nanomaterials, published more than 600 academic papers and more than 100 monographs. Hes been authorized over 100 invention patents, and proposed or participated in the formulation of multiple national standards.

Abstract: The measurement of cell temperature is helpful to the understanding of the physiological state of cells, cell events and the effect of drug treatment on cells, therefore, an important and new development direction of cell informatics. We have been focused on exploring new methods of cell temperature measurement; a Pt-W micro-nano thermocouple temperature measurement system has been built to prepare submicron temperature probes, which successfully realized the detection of single-cell temperature changes. Via this system, we have studied the different response characteristics of cells with different expression levels of protein "missing in metastasis" (MIM) under the stimulation of camptothecin and paclitaxel; a Pt resistance sensor for multi-cell temperature measurement has been constructed based on heat transfer, physical chemistry and MEMS technology, which features low heat capacity, thermal resistance and self-assembled nano-film containing amino acid functional groups that is conducive to cell adhesion and detection of weak thermal signals. The sensor was used to measure the the temperature changes of several HEK-293T cells during normal growth and apoptosis. Furthermore, the multi-cell wireless temperature measurement system was developed based on the principle of thermal resistance, which can conduct real-time non-invasive temperature detection during the normal culture process of cell. Through this system, we studied the changes of cell temperature during the process of inflammation generation and repairm  measured the temperature changes when different cold and hot drugs acted on melanoma cell line A375, and had preliminary exploration of its working mechanism.

Speakers
Lanqun Mao
(Professor of Beijing Normal University )
In Vivo Brain Chemistry Measurement

Biography:Mao Lanqun, Professor and Doctoral Supervisor at College of Chemistry, Beijing Normal University dedicated to the research of analytical chemistry, has made remarkable progress in in vivo brain chemistry measurement, regulation and functional simulation. Based on his discovery how interface electron transfer regulates the selectivity of in vivo sensing, the primary battery-type redox potential analysis method was proposed, which enabled the simulation of neurochemical signals and electrical signals and promoted the development of in vivo analytical chemistry. In 2006, he was selected as a Leading Talent in Scientific and Technological Innovation of Outstanding Youth and "Ten-thousand Talent Plan", and in 2013, under his leadership, his team was selected as an innovative research group of "the Basic Research of Analytical Chemistry for Living Organisms". Hes published 350 papers on Science, J. Am. Chem. Soc., Angew. Chem., Sci. Adv., Nature Commun. and other journals and the analysis method created by him has been used by multiple entities. He also won the second prize of National Natural Science Award in 2015 as the First Accomplisher.

Abstract:  Since it allows the study of dynamics of molecular changes in the process of life while the integrity of the structure and molecular network of living organisms (plants and animals) are better maintained, in vivo analysis has essential significance in the research of chemistry and its interdisciplinary research with life. Different from the existing chemical measurement research, in vivo analysis takes living plants or animals as the research object and therefore faces scientific and technical challenges new to the existing ones. Together with my research group, we conduct researches on the selectivity and biocompatibility of in vivo analysis research by the principles of electrochemistry, aiming to develop new principles and methods of in vivo sensing analysis, and realize the application of some sensing methods in vivo chemistry (especially in vivo brain chemistry) research.

Speakers
Xiaobing Zhang
(Professor of Hunan University)
Structural Regulation and Precision Imaging of Fluorescent Probe

Biography:Xiaobing Zhang, Professor at Hunan University, Deputy Director of HNU Academic Committee, Dean of the College of Chemistry and Chemical Engineering, Deputy Director of State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Distinguished Professor of "Yangtze River scholars Award Program", winner of the National Science Fund for Distinguished Young Scholars, Leading Talent of Science and Technology Innovation of the National Ten Thousand Plan, Fellow of the Chinese Chemical Society, Fellow of the Royal Society of Chemistry, FRSC. He was admitted by College of Chemistry and Chemical Engineering, Hunan University in 1989, where he obtained his Bachelors Degree of Organic Chemical Industry, Masters Degree of Organic Chemistry and Doctors Degree of Analytical Chemistry. After graduation, he joined the faculty of Hunan University. Between 2003 and 2005, he went to Ecole Normale Supérieure de Lyon (ENS Lyon) and Stockholm University and KTH Royal Institute of Technology for his post-doctoral researches. When he returned to China in 2005, he focused on the research of the building of innovated fluorescent probe and application of biological imaging and became a professor in 2006. He was winner of the 2nd Prize of National Natural Science Award 2020 as the First Accomplisher, the 1st Prize of National Science Award of the Ministry of Education and the 1st Prize of National Science Award of Hunan Province in 2018. He was recognized as Highly Cited Chinese Researchers 2017-2021. Since 2010, hes lead over 10 projects including key national R&D projects and key research subjects of the natural science program of national fund, and published more than 170 papers on SCI journals as corresponding author, incl. more than 30 on PNAS, Nature Commun. J. Am. Chem. Soc., Angew. Chem. Int. Ed. Hes now Associate Editor of Chemosensors and National Science Open and on the editorial committee of Science China Chemistry and Chinese Journal of Chemistry.

Abstract: The efficient acquisition of biochemical information of organisms, which is essential for human beings to explore the nature of life and provides new methods for early diagnosis of diseases and navigation in tumor surgery, has become a research hotspot in modern analytical chemistry as well as a challengeDue to its advantages such as faster response, smaller damage to samples, and real-time dynamic monitoring, etc., fluorescence imaging technology based on molecular probes has become a powerful research tool for obtaining biochemical information at the cellular and organismal level. However, with conventional fluorescence probes, it is difficult to achieve accurate imaging of cells and targets in vivo due to the challenges such as signal diffusion, limited response to specificity and background signal interference for in vivo imaging. In response to these critical issues, the team has carried out a series of researches: 1) In order to achieve accurate in situ measurement of target molecules in cells and in vivo, the team has developed a series of new in situ imaging molecular probes based on the orderly assembly mechanism of small molecular probes driven by hydrogen bonds, and established a new method for fluorescence in situ imaging analysis of small molecular probes; 2) In order to achieve highly specific acquisition of biochemical information in complex biological systems, based on the systematic study of the "structure-activity" relationship of fluorescent imaging probes, the team has proposed the strategy of developing highly selective fluorescent probes through molecular structural regulation, and developed new methods for highly selective biological imaging analysis; 3) In order to reduce the interference of background signals in biological tissues and enhance the depth of tissue imaging of traditional optical probes, the team has brought forward an innovated highly bright long-lasting luminescent material based on the electron-rich anthracene derivatives, developed a precision imaging analysis method based on long-afterglow resonance energy transfer and realized the long-lasting luminescence imaging of conscious, freely moving animals for the first time.

Speakers
Zhen Li
(Professor of Soochow University)
Treatment of Brain Diseases with Ultra-Small Nanoprobe


Speakers
He Tian
(Professor of East China University of Science and Technology, Academician of the Chinese Academy of Science)
TBD

Biography: TBD
Abstract: TBD

Speakers
Shenghong Ju
(Professor of Southeast University)
Imaging Studies of Cerebrovascular Diseases


Speakers
Xiaojun Peng
(Professor of Dalian University of Technology, Academician of the Chinese Academy of Science)
Light-driven Smart Dyes: From Target Recognition to Tumor Diagnosis and Treatment

 Biography: Professor, Dean of College of Chemical Engineering, Dalian University of Technology, CAS Member, Director of State Key laboratory of Fine Chemicals, Director of the High-end Chemical Professional Committee of China Petroleum and Chemical Industry Federation, and Director of the Daily Chemical Committee of the Chemical Industry & Engineerig Society of China. He’s mainly engaged in fine chemicals research, including high-performance dyes, fluorescent probes, organic optical materials, etc., which has seen industrial applications in the fields of digital color printing and blood cell analysis system, etc. He has won the second prize of National Technological Invention Award and the second prize of National Natural Science Award, and selected as the "highly cited scientist" in the world for many years. In 2017, he was elected as a CAS academician.

Abstract: The applications of molecular recognition, early diagnosis of tumor, surgical guidance and photodynamic therapy can be improved through smart molecular design. For example, by introducing recognition groups on dye molecules, a number of fluorescent molecular probes can be created, which has fluorescence response to different guests and environments. For example, the development of fluorescence imaging with high-level expression of characteristic enzymes in cancer cells allows the differentiation between cancer tissues, inflammatory tissues and normal tissues, providing a basis for accurate diagnosis and treatment of cancer; It can also be used for photodynamic therapy (PDT) and sonodynamic therapy (SDT) of tumors through smart modification of dye molecules. Its core lies in the target selectivity, photosensitivity and adaptability to hypoxia of dye photosensitizers.

Speakers
Yang Tian
(Professor of East China Normal University)
Analysis of Chemical Expression of Electroencephalogram Signal

 Biography: Yang Tian, Distinguished Professor of East China Normal University, is currently the Dean of School of Chemical and Molecular Engineering of East China Normal University. She was awarded the National Outstanding Youth Fund, "The distinguished lectureship award" by the Japan Chemical Society, the First Prize of the Chinese Society for Analytical Testing (first author), the First Prize of the Chinese Chemical Society for Women Analytical Chemists, and the First Prize of the Shanghai Natural Science Award (first author). Currently, she is the Associate Editor of Chemical Communications and the Associate Editor of Journal of Advanced Chemistry. Prof. Tian Yang’s team has been engaged in the field of chemical expression analysis of in vivo electrical signals for a long time, and has carried out in-depth and systematic work in the development of precise analysis and measurement strategies for biochemical molecules (such as enzymes and proteins), the establishment of long time stable and high spatial resolution imaging methods, and the development of new instruments for high-speed imaging analysis. He has published more than 160 papers,. All papers have been cited 12,000 times and selected as Elsevier China Highly Cited Scholar.

Abstract: Our group is interested in the development of biosensor for the detection of reactive oxygen species and metal ions as well as the pH value in the brain. Recently, by using a ratio Fe2+ electrochemical sensor based on Au-CC interface, it was first discovered that the uptake of extracellular Fe2+ into cortex and striatum was mediated by cAMP. which provided an insight understanding for the signaling pathway of Fe2+ entrance into neurons in the different regions of live brain. We also presented an electrochemo-physiological microarray (ECPM) for real-time recording of electrical signals and chemical signals for multiple ions in the deep brain of a free-moving rat without cross-talk. Furthermore, we constructed an anti-biological pollution fiber array to monitor the concentration of extracellular Ca2+ and the local potential of neurons in 7 different brain regions, and found that ROS has an impact on Ca2+ and neuronal death during stroke.

Speakers
Hongwei Wu
(Chair Professor of Fudan University)
Innovative Microwave and Optoelectronic Systems for Antibody-free Cell Separation


Speakers
Tao Liu
(Dalian University of Technology)
Development of Nonlinear Optical Instrument and Its Application in Medical Detection


Speakers
Mei Tian
( Professor of Fudan University)
Opportunities and Challenges of Medical Imaging from


Speakers
Hongyang Wang
(Professor of Naval Medical University, Academician of the Chinese Academy of Engineering)
Early Diagnosis and Accurate Typing are Key to Precision Treatment


Speakers
Yucai Wang
(Professor of the University of Science and Technology of China )
In Vivo Microscopic Imaging Technology and Application of Nano-pharmaceuticals


Speakers
Haibin Shi
(Professor of Soochow University)
In Vivo Imaging and Measurement
Speakers
Jianfeng Li
(Professor of ShanghaiTech University)
The PEE Strategy to Improve Quantum Yields and Hepatic Clearance of Near-Infrared II Dyes
Speakers
Kai Wang
(Professor of Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences)
Application of Nucleic Acid Based Drugs in Organism and Organoids
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